The Effect of Biodegradable Gelatin Hydrogel Microspheres on the Intervertebral Disc Regeneration Using Platelet-rich Plasma
نویسندگان
چکیده
+*Nagae, M; *Ikeda, T; *Mikami, Y; *Sawamura, K; *Hase, H; **Ozawa, H; *** Tabata, Y; **** Kawata, M; *Kubo, T +*Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine **Department of Anatomy and Neurobiology, Nippon Medical School ***Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University ****Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine [email protected]
منابع مشابه
Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres.
This study evaluated the regenerative effects of platelet-rich plasma (PRP) for the degenerated intervertebral disc (IVD) in vivo. After induction of IVD degeneration in rabbits, we prepared PRP by centrifuging blood obtained from these rabbits. These PRP were injected into the nucleus pulposus (NP) of the degenerated IVDs after impregnation into gelatin hydrogel microspheres that can immobiliz...
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OBJECTIVE To investigate the therapeutic potential of administration of gelatin hydrogel microspheres containing platelet-rich plasma (PRP), by examining its effects on progression of osteoarthritis (OA) in a rabbit model. METHODS PRP and platelet-poor plasma (PPP) were prepared from rabbit blood. Adult rabbit chondrocytes were cultured in the alginate beads with the presence of 3% PRP or 3% ...
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Intervertebral disc degeneration (IDD) is a prevalent disease that usually starts from the third decade of life and it is considered as one of the reasons contributing to social and economic problems. The results of several studies have shown that platelet-rich plasma (PRP) has the ability to stimulate cell growth and proliferation of extracellular matrix. However, studies for IDD have so far m...
متن کاملPlatelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads.
STUDY DESIGN In vitro assessment of the effects of platelet-rich plasma on the extracellular matrix metabolism of porcine intervertebral disc cells. OBJECTIVES To determine whether platelet-rich plasma is effective in stimulating cell proliferation and extracellular matrix metabolism by porcine disc cells cultured in alginate beads. SUMMARY OF BACKGROUND DATA Platelet-rich plasma is used to...
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BACKGROUND Cartilage tissue has limited regenerative capacity and the management of cartilage defects has always been a challenging issue. Platelet-rich plasma (PRP) has been recently been used to improve healing of cartilage defects. In the present experiment, we aimed to investigate the effects of PRP on regeneration capacity as well as survival of the cartilage grafts in a rabbit model. M...
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